Dominant RP in the Middle While Recessive in Both the N- and C-Terminals Due to RP1 Truncations: Confirmation, Refinement, and Questions

RP1 truncation variants, including frameshift, nonsense, and splicing, are a common cause of retinitis pigmentosa (RP).RP1 is a unique gene where truncations cause either autosomal dominant RP (adRP) or autosomal recessive RP (arRP) SANDALS depending on the location of the variants.This study aims to clarify the boundaries between adRP and arRP cau

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Undemocratic Dirac seesaw

The standard model left-handed neutrinos and several right-handed neutrinos can obtain a tiny Dirac mass matrix through their mixings with relatively heavy Dirac fermions.In this Dirac seesaw scenario, the mixings involving the left-handed neutrinos can be allowed much larger than those involving the right-handed neutrinos.This undemocratic paramet

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Who will increase their physical activity? Predictors of change in objectively measured physical activity over 12 months in the ProActive cohort

Abstract Background The aim was to identify predictors of change in objectively measured physical activity over 12 months in the ProActive cohort to improve understanding of factors influencing change in physical activity.Methods ProActive is a physical activity promotion trial that took place in Eastern England (1999-2004).365 offspring of people

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